A Subpopulation of Intracellular Neisseria gonorrhoeae Escapes Autophagy-Mediated Killing Inside Epithelial Cells.
Identifieur interne : 000402 ( Main/Exploration ); précédent : 000401; suivant : 000403A Subpopulation of Intracellular Neisseria gonorrhoeae Escapes Autophagy-Mediated Killing Inside Epithelial Cells.
Auteurs : Ping Lu [République populaire de Chine] ; Shuyi Wang [République populaire de Chine] ; Yan Lu [République populaire de Chine] ; Dante Neculai [République populaire de Chine] ; Qiming Sun [République populaire de Chine] ; Stijn Van Der Veen [République populaire de Chine]Source :
- The Journal of infectious diseases [ 1537-6613 ] ; 2019.
Descripteurs français
- KwdFr :
- Autophagie (immunologie), Autophagie (physiologie), Autophagosomes (microbiologie), Autophagosomes (métabolisme), Autophagosomes (ultrastructure), Cellules HeLa (MeSH), Cellules épithéliales (cytologie), Cellules épithéliales (microbiologie), Cellules épithéliales (métabolisme), Gentamicine (pharmacologie), Gonorrhée (métabolisme), Humains (MeSH), Interactions hôte-pathogène (physiologie), Lysosomes (métabolisme), Neisseria gonorrhoeae (immunologie), Neisseria gonorrhoeae (métabolisme), Viabilité microbienne (MeSH).
- MESH :
- cytologie : Cellules épithéliales.
- immunologie : Autophagie, Neisseria gonorrhoeae.
- microbiologie : Autophagosomes, Cellules épithéliales.
- métabolisme : Autophagosomes, Cellules épithéliales, Gonorrhée, Lysosomes, Neisseria gonorrhoeae.
- pharmacologie : Gentamicine.
- physiologie : Autophagie, Interactions hôte-pathogène.
- ultrastructure : Autophagosomes, Cellules HeLa, Humains, Viabilité microbienne.
English descriptors
- KwdEn :
- Autophagosomes (metabolism), Autophagosomes (microbiology), Autophagosomes (ultrastructure), Autophagy (immunology), Autophagy (physiology), Epithelial Cells (cytology), Epithelial Cells (metabolism), Epithelial Cells (microbiology), Gentamicins (pharmacology), Gonorrhea (metabolism), HeLa Cells (MeSH), Host-Pathogen Interactions (physiology), Humans (MeSH), Lysosomes (metabolism), Microbial Viability (MeSH), Neisseria gonorrhoeae (immunology), Neisseria gonorrhoeae (metabolism).
- MESH :
- chemical , pharmacology : Gentamicins.
- cytology : Epithelial Cells.
- immunology : Autophagy, Neisseria gonorrhoeae.
- metabolism : Autophagosomes, Epithelial Cells, Gonorrhea, Lysosomes, Neisseria gonorrhoeae.
- microbiology : Autophagosomes, Epithelial Cells.
- physiology : Autophagy, Host-Pathogen Interactions.
- ultrastructure : Autophagosomes.
- HeLa Cells, Humans, Microbial Viability.
Abstract
The bacterial pathogen Neisseria gonorrhoeae is able to transmigrate across the mucosal epithelia following the intracellular route and cause disseminated infections. It is currently unknown whether the autophagy pathway is able target intracellular N. gonorrhoeae for destruction in autolysosomes or whether this bacterium is able to escape autophagy-mediated killing. In this study, we demonstrate that during the early stage of epithelial cell invasion, N. gonorrhoeae is targeted by the autophagy pathway and sequestered into double-membrane autophagosomes that subsequently fuse with lysosomes for destruction. However, a subpopulation of the intracellular gonococci is able to escape early autophagy-mediated killing. N. gonorrhoeae is subsequently able to inhibit this pathway, allowing intracellular survival and exocytosis. During this stage, N. gonorrhoeae activates the autophagy repressor mammalian target of rapamycin complex 1 and inhibits autophagosome maturation and lysosome fusion. Thus, our results provide novel insight into the interactions between N. gonorrhoeae and the autophagy pathway during invasion and transcytosis of epithelial cells.
DOI: 10.1093/infdis/jiy237
PubMed: 29688440
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A Subpopulation of Intracellular Neisseria gonorrhoeae Escapes Autophagy-Mediated Killing Inside Epithelial Cells.</title><author><name sortKey="Lu, Ping" sort="Lu, Ping" uniqKey="Lu P" first="Ping" last="Lu">Ping Lu</name><affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology and Parasitology, School of Medicine, Zhejiang University, Hangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology and Parasitology, School of Medicine, Zhejiang University, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName></affiliation></author><author><name sortKey="Wang, Shuyi" sort="Wang, Shuyi" uniqKey="Wang S" first="Shuyi" last="Wang">Shuyi Wang</name><affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology and Parasitology, School of Medicine, Zhejiang University, Hangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology and Parasitology, School of Medicine, Zhejiang University, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName></affiliation></author><author><name sortKey="Lu, Yan" sort="Lu, Yan" uniqKey="Lu Y" first="Yan" last="Lu">Yan Lu</name><affiliation wicri:level="4"><nlm:affiliation>Department of Cell Biology and Medical Genetics, School of Medicine, Zhejiang University, Hangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Cell Biology and Medical Genetics, School of Medicine, Zhejiang University, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName></affiliation></author><author><name sortKey="Neculai, Dante" sort="Neculai, Dante" uniqKey="Neculai D" first="Dante" last="Neculai">Dante Neculai</name><affiliation wicri:level="4"><nlm:affiliation>Department of Cell Biology and Medical Genetics, School of Medicine, Zhejiang University, Hangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Cell Biology and Medical Genetics, School of Medicine, Zhejiang University, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName></affiliation></author><author><name sortKey="Sun, Qiming" sort="Sun, Qiming" uniqKey="Sun Q" first="Qiming" last="Sun">Qiming Sun</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry and Molecular Biology, School of Medicine, Zhejiang University, Hangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, School of Medicine, Zhejiang University, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName></affiliation></author><author><name sortKey="Van Der Veen, Stijn" sort="Van Der Veen, Stijn" uniqKey="Van Der Veen S" first="Stijn" last="Van Der Veen">Stijn Van Der Veen</name><affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology and Parasitology, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, School of Medicine, Zhejiang University, Hangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology and Parasitology, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, School of Medicine, Zhejiang University, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:29688440</idno><idno type="pmid">29688440</idno><idno type="doi">10.1093/infdis/jiy237</idno><idno type="wicri:Area/Main/Corpus">000571</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000571</idno><idno type="wicri:Area/Main/Curation">000571</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000571</idno><idno type="wicri:Area/Main/Exploration">000571</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A Subpopulation of Intracellular Neisseria gonorrhoeae Escapes Autophagy-Mediated Killing Inside Epithelial Cells.</title><author><name sortKey="Lu, Ping" sort="Lu, Ping" uniqKey="Lu P" first="Ping" last="Lu">Ping Lu</name><affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology and Parasitology, School of Medicine, Zhejiang University, Hangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology and Parasitology, School of Medicine, Zhejiang University, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName></affiliation></author><author><name sortKey="Wang, Shuyi" sort="Wang, Shuyi" uniqKey="Wang S" first="Shuyi" last="Wang">Shuyi Wang</name><affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology and Parasitology, School of Medicine, Zhejiang University, Hangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology and Parasitology, School of Medicine, Zhejiang University, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName></affiliation></author><author><name sortKey="Lu, Yan" sort="Lu, Yan" uniqKey="Lu Y" first="Yan" last="Lu">Yan Lu</name><affiliation wicri:level="4"><nlm:affiliation>Department of Cell Biology and Medical Genetics, School of Medicine, Zhejiang University, Hangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Cell Biology and Medical Genetics, School of Medicine, Zhejiang University, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName></affiliation></author><author><name sortKey="Neculai, Dante" sort="Neculai, Dante" uniqKey="Neculai D" first="Dante" last="Neculai">Dante Neculai</name><affiliation wicri:level="4"><nlm:affiliation>Department of Cell Biology and Medical Genetics, School of Medicine, Zhejiang University, Hangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Cell Biology and Medical Genetics, School of Medicine, Zhejiang University, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName></affiliation></author><author><name sortKey="Sun, Qiming" sort="Sun, Qiming" uniqKey="Sun Q" first="Qiming" last="Sun">Qiming Sun</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry and Molecular Biology, School of Medicine, Zhejiang University, Hangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, School of Medicine, Zhejiang University, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName></affiliation></author><author><name sortKey="Van Der Veen, Stijn" sort="Van Der Veen, Stijn" uniqKey="Van Der Veen S" first="Stijn" last="Van Der Veen">Stijn Van Der Veen</name><affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology and Parasitology, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, School of Medicine, Zhejiang University, Hangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology and Parasitology, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, School of Medicine, Zhejiang University, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName></affiliation></author></analytic><series><title level="j">The Journal of infectious diseases</title><idno type="eISSN">1537-6613</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Autophagosomes (metabolism)</term><term>Autophagosomes (microbiology)</term><term>Autophagosomes (ultrastructure)</term><term>Autophagy (immunology)</term><term>Autophagy (physiology)</term><term>Epithelial Cells (cytology)</term><term>Epithelial Cells (metabolism)</term><term>Epithelial Cells (microbiology)</term><term>Gentamicins (pharmacology)</term><term>Gonorrhea (metabolism)</term><term>HeLa Cells (MeSH)</term><term>Host-Pathogen Interactions (physiology)</term><term>Humans (MeSH)</term><term>Lysosomes (metabolism)</term><term>Microbial Viability (MeSH)</term><term>Neisseria gonorrhoeae (immunology)</term><term>Neisseria gonorrhoeae (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Autophagie (immunologie)</term><term>Autophagie (physiologie)</term><term>Autophagosomes (microbiologie)</term><term>Autophagosomes (métabolisme)</term><term>Autophagosomes (ultrastructure)</term><term>Cellules HeLa (MeSH)</term><term>Cellules épithéliales (cytologie)</term><term>Cellules épithéliales (microbiologie)</term><term>Cellules épithéliales (métabolisme)</term><term>Gentamicine (pharmacologie)</term><term>Gonorrhée (métabolisme)</term><term>Humains (MeSH)</term><term>Interactions hôte-pathogène (physiologie)</term><term>Lysosomes (métabolisme)</term><term>Neisseria gonorrhoeae (immunologie)</term><term>Neisseria gonorrhoeae (métabolisme)</term><term>Viabilité microbienne (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Gentamicins</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Cellules épithéliales</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Epithelial Cells</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Autophagie</term><term>Neisseria gonorrhoeae</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Autophagy</term><term>Neisseria gonorrhoeae</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Autophagosomes</term><term>Epithelial Cells</term><term>Gonorrhea</term><term>Lysosomes</term><term>Neisseria gonorrhoeae</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Autophagosomes</term><term>Cellules épithéliales</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Autophagosomes</term><term>Epithelial Cells</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Autophagosomes</term><term>Cellules épithéliales</term><term>Gonorrhée</term><term>Lysosomes</term><term>Neisseria gonorrhoeae</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Gentamicine</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Autophagie</term><term>Interactions hôte-pathogène</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Autophagy</term><term>Host-Pathogen Interactions</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Autophagosomes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>HeLa Cells</term><term>Humans</term><term>Microbial Viability</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="fr"><term>Autophagosomes</term><term>Cellules HeLa</term><term>Humains</term><term>Viabilité microbienne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The bacterial pathogen Neisseria gonorrhoeae is able to transmigrate across the mucosal epithelia following the intracellular route and cause disseminated infections. It is currently unknown whether the autophagy pathway is able target intracellular N. gonorrhoeae for destruction in autolysosomes or whether this bacterium is able to escape autophagy-mediated killing. In this study, we demonstrate that during the early stage of epithelial cell invasion, N. gonorrhoeae is targeted by the autophagy pathway and sequestered into double-membrane autophagosomes that subsequently fuse with lysosomes for destruction. However, a subpopulation of the intracellular gonococci is able to escape early autophagy-mediated killing. N. gonorrhoeae is subsequently able to inhibit this pathway, allowing intracellular survival and exocytosis. During this stage, N. gonorrhoeae activates the autophagy repressor mammalian target of rapamycin complex 1 and inhibits autophagosome maturation and lysosome fusion. Thus, our results provide novel insight into the interactions between N. gonorrhoeae and the autophagy pathway during invasion and transcytosis of epithelial cells.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29688440</PMID><DateCompleted><Year>2019</Year><Month>11</Month><Day>14</Day></DateCompleted><DateRevised><Year>2019</Year><Month>11</Month><Day>14</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1537-6613</ISSN><JournalIssue CitedMedium="Internet"><Volume>219</Volume><Issue>1</Issue><PubDate><Year>2019</Year><Month>01</Month><Day>01</Day></PubDate></JournalIssue><Title>The Journal of infectious diseases</Title><ISOAbbreviation>J Infect Dis</ISOAbbreviation></Journal><ArticleTitle>A Subpopulation of Intracellular Neisseria gonorrhoeae Escapes Autophagy-Mediated Killing Inside Epithelial Cells.</ArticleTitle><Pagination><MedlinePgn>133-144</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/infdis/jiy237</ELocationID><Abstract><AbstractText>The bacterial pathogen Neisseria gonorrhoeae is able to transmigrate across the mucosal epithelia following the intracellular route and cause disseminated infections. It is currently unknown whether the autophagy pathway is able target intracellular N. gonorrhoeae for destruction in autolysosomes or whether this bacterium is able to escape autophagy-mediated killing. In this study, we demonstrate that during the early stage of epithelial cell invasion, N. gonorrhoeae is targeted by the autophagy pathway and sequestered into double-membrane autophagosomes that subsequently fuse with lysosomes for destruction. However, a subpopulation of the intracellular gonococci is able to escape early autophagy-mediated killing. N. gonorrhoeae is subsequently able to inhibit this pathway, allowing intracellular survival and exocytosis. During this stage, N. gonorrhoeae activates the autophagy repressor mammalian target of rapamycin complex 1 and inhibits autophagosome maturation and lysosome fusion. Thus, our results provide novel insight into the interactions between N. gonorrhoeae and the autophagy pathway during invasion and transcytosis of epithelial cells.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lu</LastName><ForeName>Ping</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Parasitology, School of Medicine, Zhejiang University, Hangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Shuyi</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Parasitology, School of Medicine, Zhejiang University, Hangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lu</LastName><ForeName>Yan</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Cell Biology and Medical Genetics, School of Medicine, Zhejiang University, Hangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Neculai</LastName><ForeName>Dante</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Cell Biology and Medical Genetics, School of Medicine, Zhejiang University, Hangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sun</LastName><ForeName>Qiming</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Department of Biochemistry and Molecular Biology, School of Medicine, Zhejiang University, Hangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van der Veen</LastName><ForeName>Stijn</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Parasitology, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, School of Medicine, Zhejiang University, Hangzhou, China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Infect Dis</MedlineTA><NlmUniqueID>0413675</NlmUniqueID><ISSNLinking>0022-1899</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005839">Gentamicins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000071182" MajorTopicYN="N">Autophagosomes</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName><QualifierName UI="Q000648" MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001343" MajorTopicYN="N">Autophagy</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004847" MajorTopicYN="N">Epithelial Cells</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005839" MajorTopicYN="N">Gentamicins</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006069" MajorTopicYN="N">Gonorrhea</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006367" MajorTopicYN="N">HeLa Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D054884" MajorTopicYN="N">Host-Pathogen Interactions</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008247" MajorTopicYN="N">Lysosomes</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D050296" MajorTopicYN="N">Microbial Viability</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009344" MajorTopicYN="N">Neisseria gonorrhoeae</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>02</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2018</Year><Month>04</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>4</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>11</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>4</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29688440</ArticleId><ArticleId IdType="pii">4982933</ArticleId><ArticleId IdType="doi">10.1093/infdis/jiy237</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Zhejiang</li></region><settlement><li>Hangzhou</li></settlement><orgName><li>Université de Zhejiang</li></orgName></list><tree><country name="République populaire de Chine"><region name="Zhejiang"><name sortKey="Lu, Ping" sort="Lu, Ping" uniqKey="Lu P" first="Ping" last="Lu">Ping Lu</name></region><name sortKey="Lu, Yan" sort="Lu, Yan" uniqKey="Lu Y" first="Yan" last="Lu">Yan Lu</name><name sortKey="Neculai, Dante" sort="Neculai, Dante" uniqKey="Neculai D" first="Dante" last="Neculai">Dante Neculai</name><name sortKey="Sun, Qiming" sort="Sun, Qiming" uniqKey="Sun Q" first="Qiming" last="Sun">Qiming Sun</name><name sortKey="Van Der Veen, Stijn" sort="Van Der Veen, Stijn" uniqKey="Van Der Veen S" first="Stijn" last="Van Der Veen">Stijn Van Der Veen</name><name sortKey="Wang, Shuyi" sort="Wang, Shuyi" uniqKey="Wang S" first="Shuyi" last="Wang">Shuyi Wang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Bois/explor/RapamycinFungusV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000402 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000402 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Bois
|area= RapamycinFungusV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:29688440
|texte= A Subpopulation of Intracellular Neisseria gonorrhoeae Escapes Autophagy-Mediated Killing Inside Epithelial Cells.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:29688440" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a RapamycinFungusV1
| This area was generated with Dilib version V0.6.38. |  |